Data/hora: 19/05/2024 04:19:18

Provedor de dados: 	Genetics and Molecular Biology	
País: 	Brazil	
Título: 	A never-ending story: the steadily growing family of the FA and FA-like genes	
Autores: 	Gueiderikh,Anna; Rosselli,Filippo; Neto,Januario B.C.	
Data: 	2017-06-01	
Ano: 	2017	
Palavras-chave: 	DNA repair; Leukemia; Fanconi anemia; Chromosomal abnormalities.	
Resumo: 	Abstract Among the chromosome fragility-associated human syndromes that present cancer predisposition, Fanconi anemia (FA) is unique due to its large genetic heterogeneity. To date, mutations in 21 genes have been associated with an FA or an FA-like clinical and cellular phenotype, whose hallmarks are bone marrow failure, predisposition to acute myeloid leukemia and a cellular and chromosomal hypersensitivity to DNA crosslinking agents exposure. The goal of this review is to trace the history of the identification of FA genes, a history that started in the eighties and is not yet over, as indicated by the cloning of a twenty-first FA gene in 2016.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300398	
Editor: 	Sociedade Brasileira de Genética	
Relação: 	10.1590/1678-4685-gmb-2016-0213	
Formato: 	text/html	
Fonte: 	Genetics and Molecular Biology  v.40 n.2 2017	
Fonte: 	info:eu-repo/semantics/openAccess